Charged hadronic four-body decays of D 0 mesons have been studied in the E687 photoproduction experiment at Fermilab. Branching ratios relative to the D 0 → K − π + π + π − decay mode for the Cabibbo-suppressed decays D 0 → π − π + π − π + , D 0 → K − K + π − π + have been measured and the first evidence of the D 0 → K − K + K − π + decay mode is reported. An analysis of the D 0 → K − K + π − π + resonance structure is also presented.